Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Schematic presentation of TEAD1/4 regulation by miR-377-3p, miR-1343-3p and miR-4269 in GC. TEAD1/4 showed low expression in normal gastric epithelium cells, which was partially inhibited by miR-377-3p, miR-1343-3p and miR-4269. However, the related miRNA showed decreased expression in GC, thus they loss the inhibition on TEAD1 and TEAD4. Via MST–YAP1 axis, YAP1–TEAD1/4 complex was translocated into the nucleus to promote gastric tumorigenesis by regulating the downstream expression.
