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. 2017 Nov 20;8:1551. doi: 10.3389/fimmu.2017.01551

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Copyright © 2017 Mensah, Roetynck, Kanteh, Bowyer, Ndaw, Oko, Bliss, Jagne, Cortese, Nicosia, Roberts, D’Alessio, Leroy, Faye, Kampmann, Cisse, Bojang, Gerry, Viebig, Lawrie, Clarke, Imoukhuede, Ewer, Hill and Afolabi.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Ex vivo IFNγ enzyme-linked immunospot responses to multiple epitope string thrombospondin-related adhesion protein (ME-TRAP) pre- and post-vaccination with ChAd63 and MVA ME-TRAP in Gambian infants. (A–C) Scatter plots show individual responses to ME-TRAP in both vaccinees (in black) and controls (in white) of each age group. (A) 16-week-old; (B) 8-week-old; (C) 1-week-old infants. (D) Geometric mean ME-TRAP responses in each age group over period of follow-up. LLD, lower limit of detection of the assay. Increases in responses over the time course were analyzed using two-tailed Friedman test. Responses between individual time points were compared within each age group using two-tailed Wilcoxon analysis, *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001. Lines and numbers in blue denote geometric mean. Numbers shown in black represent the percentage of responders among the vaccinated infants for each time point.