Table 2.
Systemic solicited adverse events during 3-day follow-up after each study vaccination.
| Post-ChAd63 multiple epitope string thrombospondin-related adhesion protein (ME-TRAP) |
Post-MVA ME-TRAP |
|||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Age group |
16 weeks |
8 weeks |
1 week |
16 weeks |
8 weeks |
1 weeks |
||||||
| n (%) | Vaccine | Control | Vaccine | Control | Vaccine | Control | Vaccine | Control | Vaccine | Control | Vaccine | Control |
| Reported fever | 1 (6.7) | 5 (100.0) | 7 (46.7) | 5 (100.0) | 14 (93.3) | 7 (70.0) | 2 (13.3) | 0 | 4 (26.7) | 2 (40.0) | 15 (100.0) | 7 (70.0) |
| Documented fever | 11 (73.3) | 4 (80.0) | 10 (66.7) | 1 (20.0) | 8 (53.3) | 1 (10.0) | 10 (66.7) | 1 (20.0) | 12 (80.0) | 2 (40.0) | 9 (60.0) | 1 (10.0) |
| Excessive crying | 8 (53.3) | 3 (60.0) | 6 (40.0) | 4 (80.0) | 10 (66.7) | 4 (40.0) | 2 (13.3) | 0 | 10 (66.7) | 2 (40.0) | 9 (60.0) | 3 (30.0) |
| Refusal of feed | 1 (6.7) | 1 (20.0) | 1 (6.7) | 0 | 1 (6.7) | 0 | 0 | 0 | 3 (20.0) | 0 | 1 (6.7) | 0 |
| Vomiting | 1 (6.7) | 0 | 2 (13.3) | 2 (40.0) | 2 (13.3) | 1 (10.0) | 0 | 0 | 6 (40.0) | 0 | 1 (6.7) | 2 (20.0) |
| Diarrhea | 8 (53.3) | 1 (20.0) | 3 (20.0) | 1 (20.0) | 5 (33.3) | 2 (20.0) | 0 | 0 | 5 (33.3) | 0 | 3 (20.0) | 1 (10.0) |
This table shows that following ChAd63 and MVA ME-TRAP administrations, fever, excessive crying, refusal of feed, vomiting, and diarrhea were more frequently observed among 1- and 8-week-old cohorts than 16-week-old cohort.