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. 2017 Nov 22;8:860. doi: 10.3389/fphar.2017.00860

FIGURE 5.

FIGURE 5

Kinetics of ion channel currents in hP2X4/hP2X7-coexpressing oocytes. Two-electrode voltage clamp measurements of currents in Xenopus oocytes expressing hP2X4 and hP2X7 receptors were elicited by the application of 0.1 mM ATP. (A) Mean current traces were recorded from oocytes expressing hP2X4 or hP2X7 subunits alone or together, as indicated. (B) Mean currents in oocytes coexpressing hP2X4 and hP2X7 were compared with the sum of those in oocytes expressing hP2X4 or hP2X7 alone. The mean current amplitudes were not significantly different at any time point, indicating that P2X4/P2X7 heteromers with distinct current kinetics are not formed. Data are the means ± SD from five oocytes at each time point.