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. 2017 Nov 22;8:860. doi: 10.3389/fphar.2017.00860

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Copyright © 2017 Schneider, Prudic, Pippel, Klapperstück, Braam, Müller, Schmalzing and Markwardt.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effect of ivermectin on ATP-induced currents of hP2X4/hP2X7-coexpressing oocytes. (A–C) Two-electrode voltage clamp measurements showing the effect of ivermectin (3 μM) on ATP-induced currents of oocytes expressing (A) hP2X4, (B) hP2X7, or (C) hP2X4 + hP2X7. Oocytes were incubated for 1 min with 3 μM ivermectin, and then with 3 μM ivermectin + 0.1 mM ATP. (D) Current amplitudes measured in P2X4/P2X7-coexpressing oocytes during ivermectin application were compared with the sum of the P2X4- and P2X7-dependent current amplitudes (as shown in parts A,B, respectively). Mean current amplitudes were not significantly different at any time point, indicating the lack of a distinct P2X4/P2X7 phenotype related to ivermectin. This may be explained by ivermectin affecting only homomeric P2X4 receptors. Data are the means ± SD from 4–6 oocytes.