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. 2017 Nov 22;8:860. doi: 10.3389/fphar.2017.00860

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Copyright © 2017 Schneider, Prudic, Pippel, Klapperstück, Braam, Müller, Schmalzing and Markwardt.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effect of PSB-14517 on ATP-induced currents of hP2X4/hP2X7-coexpressing oocytes. Two-electrode voltage clamp measurements showing ATP-induced current amplitudes (I_act,3s) at 3 s after the application of 0.1 mM ATP. The theoretical current remaining after PSB-14517 application to hP2X4/hP2X7-expressing oocytes (rightmost column) was calculated as described in Section “Results.” The theoretical current amplitude was not significantly different from the measured value (next to rightmost column), indicating the lack of a distinct P2X4/P2X7 phenotype related to PSB-14517, which may be explained by PSB-14517 affecting only homomeric P2X4 receptors. Data are means ± SD from 4–11 oocytes.