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Structural comparison of E69 and its homologs, E25 (PDB: 4Q05) and EstE5 (PDB: 3FAK). (A) Electrostatic surface representations of E69 and its homologs, from -3.5 (red) to +3.5 kT/e (blue). Surface view of the structures showing the differences in (B) the cap domains and (C) the substrate-binding pockets. The cap domains and active sites are indicated in blue and red, respectively.
