Fig. 1.

Beta value for duration of disease ± standard errors for standardized regional volume.

Beta value was calculated from mixed effect model where the volumes of subcortical structures, lateral ventricles and ICV were used as a dependent variable and age, sex, duration of illness, chlorpromazine equivalent daily dose of antipsychotics and ICV were used as independent variables, and type of protocol was incorporated as a random effect. accumb, accumbens; amyg, amygdala; caud, caudate; hippo, hippocampus; ICV, intracranial volume; L, left; LatVent, lateral ventricle; pal, pallidum; put, putamen; R, right; thal, thalamus.