Table 2.
ROI Analysis of uncorrected and corrected MD values and volumes, controlled for age, gender, years of education and MRI protocol.
| Mean (SD) MD in mm2/s × 10− 3 Volume in ml |
ANCOVA |
|||||||
|---|---|---|---|---|---|---|---|---|
| AD | MCI | HC | F | p (unc.) | Partial eta2 | Post hoc t-tests, p < 0.05 | ||
| Left hippocampus | MD without PVC | 1.22 (0.13) | 1.15 (0.08) | 1.10 (0.08) | 14.61 | < 0.001 | 0.21 | AD > MCI, AD > HC |
| MD with PVC | 1.05 (0.10) | 1.02 (0.072) | 0.99 (0.07) | 5.59 | < 0.01 | 0.09 | AD > HC AD > MCI† |
|
| Volume | 3.77 (0.67) | 4.44 (0.64) | 4.82 (0.51) | 30.16 | < 0.001 | 0.35 | AD < MCI < HC | |
| Right hippocampus | MD without PVC | 1.26 (0.13) | 1.19 (0.07) | 1.15 (0.08) | 13.98 | < 0.001 | 0.23 | AD > MCI, AD > HC |
| MD with PVC | 1.10 (0.09) | 1.07 (0.06) | 1.05 (0.06) | 4.9 | < 0.01 | 0.08 | AD > MCI† AD > HC |
|
| Volume | 2.40 (0.48) | 2.85 (0.38) | 3.02 (0.32) | 26.62 | < 0.001 | 0.33 | AD < MCI AD < HC |
|
| PCC | MD without PVC | 1.24 (0.16) | 1.14 (0.10) | 1.11 (0.09) | 19.68 | < 0.001 | 0.26 | AD > MCI, AD > HC |
| MD with PVC | 1.05 (0.15) | 0.98 (0.10) | 0.95 (0.09) | 15.46 | < 0.001 | 0.22 | AD > MCI, AD > HC | |
| Volume | 11. 93 (1.16) | 13.51 (1.11) | 13.89 (1.29) | 28.38 | < 0.001 | 0.34 | AD < MCI AD < HC |
|
† Post hoc comparisons revealed a trend (p < 0.1).