Table 3.

Results of the logistic regression analysis, controlled for age, gender, years of education and MRI protocol.

Diagnosis	ROI	PVC	MD		Volume
			β	AUC [95% CI]	β	AUC [95% CI]
MCI vs. HC	Left hippocampus	With PVC	0.55†	0.67 [0.54, 0.78]	− 0.85**	0.72 [0.60, 0.83]
		Without PVC	0.65*	0.69 [0.56, 0.81]
	Right hippocampus	With PVC	0.46	0.64 [0.51, 0.76]	− 0.62*	0.68° [0.56, 0.80]
		Without PVC	0.73*	0.71 [0.59, 0.82]
	Posterior cingulate cortex	With PVC	0.39	0.63 [0.50, 0.75]	− 0.32	0.62 [0.49, 0.74]
		Without PVC	0.39	0.63 [0.50, 0.75]
AD vs. HC	Left hippocampus	With PVC	1.07**	0.72 [0.61, 0.83]	− 2.64***	0.90°° [0.81, 0.96]
		Without PVC	1.89***	0.82°° [0.72, 0.90]
	Right hippocampus	With PVC	0.92**	0.71 [0.59, 0.82]	− 2.22***	0.87°° [0.78, 0.94]
		Without PVC	1.65***	0.81°°° [0.70, 0.90]
	Posterior cingulate cortex	With PVC	2.27***	0.81 [0.70, 0.90]	− 2.23***	0.88° [0.80, 0.95]
		Without PVC	2.54***	0.84°° [0.74, 0.92]
AD vs. MCI	Left hippocampus	With PVC	0.45	0.61 [0.48, 0.73]	− 1.40***	0.79°° [0.69, 0.89]
		Without PVC	1.07**	0.72°°° [0.60, 0.83]
	Right hippocampus	With PVC	0.41	0.57 [0.44, 0.70]	− 1.29***	0.78°° [0.67, 0.88]
		Without PVC	1.06**	0.71°°° [0.59, 0.82]
	Posterior cingulate cortex	With PVC	1.81***	0.75 [0.64, 0.86]	− 1.73***	0.84° [0.75, 0.92]
		Without PVC	2.05***	0.79° [0.68, 0.89]

Standardized regression weights (β) resulting from logistic regression analysis. The confidence intervals of the area under the receiver operator characteristic curve (AUC) were calculated using bootstrapping.

Asterisks (*) indicate significance of the standardized regression weights (***p < 0.001, **p < 0.01, *p < 0.05, ^†p < 0.1¸). Circles (°) indicate significantly larger AUCs compared to the AUC of the MD_PVC model, determined using bootstrapping (°p < 0.1, °°p < 0.01, °°°p < 0.001). None of the other AUCs differed significantly.