Table 4.
Cognitive scores: adjusted group means (+SE) for the placebo and PBT groups for the double blind and open-label phases of the IMAGINE trial
| Cognitive scores | Double blind |
Open label |
||||
|---|---|---|---|---|---|---|
| 0–12 Mo Δ/yr |
12–24 Mo Δ/yr |
0–24 Mo Δ/yr |
||||
| Placebo N = 12 | PBT2 N = 21 | Placebo N = 11 | PBT2 N = 16 | All N = 27 | PBT2 N = 27 | |
| Category fluency | 10.95 (0.86) | 9.74 (0.63) | 7.77 (1.16) | 10.9 (0.94) | 9.34 (0.70) | 9.38 (0.69) |
| Verbal fluency | 25.37 (2.60) | 30.46 (1.89) | 28.38 (2.28) | 27.43 (1.84) | 27.90 (1.35) | 27.23 (1.78) |
| RAVLT acquisition | 34.98 (3.13) | 37.1 (2.27) | 27.86 (2.29) | 35.04 (2.29) | 31.45 (1.70) | 30.99 (2.30) |
| RAVLT delay | 2.44 (0.82) | 2.65 (0.57) | 1.98 (0.46) | 1.77 (0.37) | 1.87 (0.28) | 1.83 (0.49) |
| Trial making B | 160.24 (12.69) | 167.36 (9.48) | 106.73 (21.01) | 99.48 (17.14) | 103.10 (12.10) | 102.27 (12.59) |
| Digit span | 13.38 (0.98) | 14.79 (0.71) | 13.71 (0.82) | 13.45 (0.65) | 13.58 (0.48) | 13.49 (0.57) |
Abbreviation: RAVLT, Rey Auditory Verbal Learning Test.