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. Author manuscript; available in PMC: 2017 Nov 27.
Published in final edited form as: J Am Chem Soc. 2015 Apr 2;137(14):4598–4601. doi: 10.1021/ja511298n

Figure 1.

Figure 1

Schematic representation of CTB's function and role in initiating chondrogenesis. (a) If DNA (black line) is tightly coiled around histone proteins (blue cylinders), transcriptional activity and subsequent gene expression are inhibited. Activation of histone acetyltransferase (HAT) via the CTB molecule loosens the DNA making target binding sites available for transcription. (b) CTB is functionalized on the NanoScript platform, and the resulting construct is delivered to adipose-derived mesenchymal stem cells (ADMSCs) to enhance overexpression of targeted genes. The NanoScript construct is also modified with additional small molecules that target and overexpress the Sox9 gene. (c) Activation of the Sox9 gene in ADMSCs guides enhanced differentiation into the chondrogenic lineage.