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The impact of pH on the solubility and absorption of pictilisib: illustrated from the in vitro solubility assessment of pictilisib and the mechanistic understanding of stomach emptying process. (a) In vitro solubility vs. pH profile for pictilisib. (b) Stomach emptying physiology. (c) The impact of stomach emptying physiology on the absorption of pictilisib in fed state ((a,b), gastric filling and gastric mixing; (c), gastric emptying).
