Figure 1.

Schematic presentation of the IGI model. The model includes total glucose, insulin, regulation of glucose production, second‐phase insulin secretion, and glucose elimination. Full arrows indicate flows and broken arrows indicate control mechanisms. G_C and G_P, central and peripheral compartments of glucose; G_E1 and G_E2, effect compartments for control of glucose production and insulin secretion; I, insulin disposition compartment; I_FPS, delay compartment the first‐phase insulin secretion; I_E, effect compartment for control of glucose elimination; Q, CL_G, and CL_GI, clearance parameters of the glucose model; EGP, endogenous glucose production; CL_I and k_IS, parameters of the insulin model; k_GE1, k_GE2, and k_IE, rate constants of the effect compartments.4