Table 1.
Summary of rat multilevel brain and CSFs data for model evaluation
| Acetaminophen | Atenolol | Methotrexate | Morphine | Morphine | Paliperidone | Phenytoin | Quinidine | Raclopride | Remoxipride | Remoxipride | Risperidone | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Study design | ||||||||||||
| No. of animals | 16 | 5 | 23 | 65 | 18 | 21 | 14 | 41 | 19 | 29 | 65 | 16 |
| Dosage, mg/kg (infusion time, min) | 15 (10) | 10 (1) | 40, 80 (10) | 4, 10, 40 (10) | 10, 40 (10) | 0.5 (20) | 20, 30, 40 (10) | 10, 20 (10) | 0.56 (10) | 4, 8, 16 (30) | 0.7, 5.2, 14 (10) | 2 (20) |
| Data | ||||||||||||
| Plasma | X | X | X | X | X | X | X | X | X | X | X | X |
| BrainECF | X | X | X | X | X | X | X | X | X | X | X | X |
| CSFLV | X | X | X | X | ||||||||
| CSFCM | X | X | X | X | X | X | ||||||
| Total brain tissue | X | X | X (new data) | X (new data) | ||||||||
| References | 24 | 25 | 23 | 26 | 27 | 9 | 9 | 28 | 30 (except total brain tissue data) | 9 (except total brain tissue data) | 9 | |
BrainECF, brain extracellular fluid compartment; CSFLV, cerebrospinal fluid compartment in the lateral ventricle; CSFCM, cerebrospinal fluid compartment in the cisterna magna.