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. Author manuscript; available in PMC: 2017 Nov 27.
Published in final edited form as: Pediatr Blood Cancer. 2016 Oct 27;64(4):10.1002/pbc.26278. doi: 10.1002/pbc.26278

TABLE 1.

Predictors of EFS

Training cohort, N = 562 Validation cohort, N = 541


Univariate Multivariable Multivariable stepwise selection Univariate




# % HR p HR P HR P # %
Gender: Male 562 53.9 0.79 0.32 541 47.9

Age < 13 562 23.1 0.83 0.55 541 26.1

Race: 542 0.93 532

 White (reference) 77.3 1 n/a 82.3

 Black 13.3 0.66 0.29 10.2

 Asian 3.5 1.05 0.94 2.4

 Native American 0.2 0.00 0.99 0.38

 Hawaii/Pacific Isl. 0.4 0.00 0.99 0

 Other 5.3 0.71 0.57 4.7

Race: black vs. other 542 13.3 0.64 0.28 532 10.2

Hispanic 542 12.6 0.65 0.34 529 17.2

Histology 538 0.57 516

 NS (reference) 86.6 1 n/a 86.6

 MC 7.8 0.62 0.35 8.5

 LP 5.4 0.44 0.25 4.5

 LD 0.2 0.00 0.99 0.4

Histology: NS 538 86.6 1.82 0.18 0.94 0.90 516 86.6

Histology: MC 538 7.8 0.66 0.44 516 8.5

Stage: versus stage 4 562 0.13 541

 1 5.5 0.44 0.18 6.1

 2 59.3 0.63 0. 08 58.6

 3 18.0 0.45 0.04 20.2

 4 (reference) 17.3 1 n/a 15.2

Stage: 4 562 17.3 1.83 0.035 2.36 0.0054 2.31 0.004 541 15.2

Large mediastinal mass 541 44.0 2.81 <0.001 2.60 0.0006 2.70 <0001 522 40.8

Nodal aggregates ≥ 6 cm 549 55.9 1.36 0.22 532 57.7

Bulk disease 558 75.8 2.73 0.0049 537 76.4

Involved sites < 3 492 67.7 1.05 0.85 478 69.0

Extralymphatic 538 26.0 1.10 0.73 508 23.8

B symptoms 562 23.7 2.02 0.0062 539 21.2

Weight loss 556 10.3 1.54 0.23 533 10.7

Night sweats 560 15.0 2.11 0.011 539 13.7

Fever 561 10.7 2.32 0.0086 2.33 0.017 2.26 0.011 537 8.8

Hemoglobin < 10.5 548 18.6 1.43 0.22 1.02 0.96 530 23.2

Albumin < 3.5 541 30.7 1.89 0.012 1.45 0.18 1.56 0.073 519 30.3

ESR < 20 531 18.8 0.49 0.064 0.55 0.26 513 19.1

ESR < 50 531 55.2 0.67 0.11 513 53.8