TABLE 1.

Predictors of EFS

	Training cohort, N = 562								Validation cohort, N = 541
	Univariate				Multivariable		Multivariable stepwise selection		Univariate
	#	%	HR	p	HR	P	HR	P	#	%
Gender: Male	562	53.9	0.79	0.32					541	47.9
Age < 13	562	23.1	0.83	0.55					541	26.1
Race:	542			0.93					532
White (reference)		77.3	1	n/a						82.3
Black		13.3	0.66	0.29						10.2
Asian		3.5	1.05	0.94						2.4
Native American		0.2	0.00	0.99						0.38
Hawaii/Pacific Isl.		0.4	0.00	0.99						0
Other		5.3	0.71	0.57						4.7
Race: black vs. other	542	13.3	0.64	0.28					532	10.2
Hispanic	542	12.6	0.65	0.34					529	17.2
Histology	538			0.57					516
NS (reference)		86.6	1	n/a						86.6
MC		7.8	0.62	0.35						8.5
LP		5.4	0.44	0.25						4.5
LD		0.2	0.00	0.99						0.4
Histology: NS	538	86.6	1.82	0.18	0.94	0.90			516	86.6
Histology: MC	538	7.8	0.66	0.44					516	8.5
Stage: versus stage 4	562			0.13					541
1		5.5	0.44	0.18						6.1
2		59.3	0.63	0. 08						58.6
3		18.0	0.45	0.04						20.2
4 (reference)		17.3	1	n/a						15.2
Stage: 4	562	17.3	1.83	0.035	2.36	0.0054	2.31	0.004	541	15.2
Large mediastinal mass	541	44.0	2.81	<0.001	2.60	0.0006	2.70	<0001	522	40.8
Nodal aggregates ≥ 6 cm	549	55.9	1.36	0.22					532	57.7
Bulk disease	558	75.8	2.73	0.0049					537	76.4
Involved sites < 3	492	67.7	1.05	0.85					478	69.0
Extralymphatic	538	26.0	1.10	0.73					508	23.8
B symptoms	562	23.7	2.02	0.0062					539	21.2
Weight loss	556	10.3	1.54	0.23					533	10.7
Night sweats	560	15.0	2.11	0.011					539	13.7
Fever	561	10.7	2.32	0.0086	2.33	0.017	2.26	0.011	537	8.8
Hemoglobin < 10.5	548	18.6	1.43	0.22	1.02	0.96			530	23.2
Albumin < 3.5	541	30.7	1.89	0.012	1.45	0.18	1.56	0.073	519	30.3
ESR < 20	531	18.8	0.49	0.064	0.55	0.26			513	19.1
ESR < 50	531	55.2	0.67	0.11					513	53.8