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. Author manuscript; available in PMC: 2017 Nov 27.
Published in final edited form as: Int J Biochem Cell Biol. 2016 Aug 30;79:139–150. doi: 10.1016/j.biocel.2016.08.023

Fig. 8. A functional OB-R/VEGFR/Notch axis stimulates leptin-induced angiogenic features in endothelial cells.

Fig. 8

Leptin-induces Notch expression in endothelial cells through activation of VEGFR-1 and VEGFR-2 in the absence of VEGF. Leptin induces VEGFR-2 expression and transphosphorylation at Y951, Y966, and Y1175, that in turn induces the expression of Notch genes/proteins. These effects of leptin increase endothelial cell proliferation, S-phase progression, and tube formation. Inhibition of OB-R, VEGFR-2 or Notch signaling negatively impacts leptin pro-angiogenic effects in endothelial cells.