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. Author manuscript; available in PMC: 2017 Nov 28.
Published in final edited form as: Nat Genet. 2017 May 1;49(6):925–934. doi: 10.1038/ng.3844

Figure 6. DUX binds directly to ‘2C’ gene promoters and retrotransposons.

Figure 6

(a) Top enriched ‘MGI expression’ and ‘Gene Ontology (GO)’ terms identified in the 3,881 genes bound by DUX [two replicates]. (b) Overlap of DUX-ChIP occupied genes with genes: upregulated in unsorted mESCs post Dux overexpression (left panel); enriched in ‘2C-like’ cells (middle panel); and driven by MERVL elements (right panel) [Statistics determined by hypergeometric test]. Screenshots demonstrating the overlap of DUX-ChIP occupancy (yellow box) with the acquisition of 2-Cell embryo-like open chromatin and gene/MERVL expression (green box).