Table 5.
Symptoms of cough and progressively worsening dyspnea |
Physical examination notable for PH* and/or congestive heart failure† |
Hypoxemia |
PH on echocardiography or right heart catheterization (elevated mean PAP; normal PAOP; increased PVR) |
Anemia, thrombocytopenia, elevated LDH, elevated D-dimer on laboratory analysis |
Chest CT findings of inter- and intra-lobular septal thickening, lymphadenopathy, nodules, and GGO |
Pulmonary tissue histology revealing pulmonary arteriopathy +/– pulmonary venopathy +/– involvement of lymphatics |
Presence of malignancy (carcinoma most common) |
PH on exam includes split S2 with a loud P2 component; LDH, lactate dehydrogenase.
Heart failure on exam includes jugular venous distension, S3 heart sound, lower extremity edema, and pulsatile liver at right upper quadrant.
PAP, pulmonary artery pressure; PAOP, pulmonary artery occlusion pressure; PVR, pulmonary vascular resistance; GGO, ground-glass opacification.