Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2017 Nov 24;10:5621–5631. doi: 10.2147/OTT.S150701

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2017 He et al. This work is published and licensed by Dove Medical Press Limited

The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.

PMC Copyright notice

Effects of GLP-1R agonists on mitochondrial respiration and glycolysis in PTC cell lines.

Notes: PTC cells were treated with liraglutide or exenatide (100 nmol/L) for 48 h. Oligomycin (1 μM), FCCP (0.25 μM), rotenone (1 μM), and antimycin A (1 μM) were delivered at the indicated times to determine different parameters of mitochondrial functions; glucose (10 mM), oligomycin (1.0 μM), and 2-deoxy-D-glucose (100 mM) were delivered at indicated times to determine different parameters of glycolysis status. These drugs were added according to the manufacturer’s protocols. (A) IHH4, (B) BCPAP, and (C) TPC-1.

Abbreviations: BCPAP, normal human thyroid cells; ECAR, extracellular acidification rate; FCCP, p-trifluoromethoxyphenylhydrazone; GLP-1R, glucagon-like peptide-1 receptor; IHH4, human papillary thyroid carcinoma cell line; OCR, oxygen consumption rate; PTC, papillary thyroid cancer; TPC-1, human thyroid cancer cell line.