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Fragment hits for three epigenetic targets. Panel A: Overview of fragment hit binding sites in JMJD2D (A1), the BRD1 bromodomain (A2) and the ATAD2 bromodomain (A3); the active site of JMJD2D is buried. Panels B: Interaction of exemplar fragment hits with JMJD2D (B1), BRD1 (B2) and ATAD2 (B3).
