Table 2.
Patient characteristics of Cohort 2 (reconstructed cohort)
| Patient characteristics | Full cohort
|
Propensity-score-matched Cohort
|
||||||
|---|---|---|---|---|---|---|---|---|
| Low-dose ASA initiators
|
Non-initiators
|
Low-dose ASA initiators
|
Non-initiators
|
|||||
| N=403,693 | % | N=3,195,091 | % | N=367,326 | % | N=367,326 | % | |
| Age groups (years) | ||||||||
| <50 | 36,701 | 9 | 1,565,801 | 49 | 34,298 | 9 | 30,124 | 8 |
| 50–59 | 73,674 | 18 | 683,695 | 21 | 66,717 | 18 | 65,087 | 18 |
| 60–69 | 120,820 | 30 | 541,482 | 17 | 110,120 | 30 | 110,012 | 30 |
| 70–79 | 101,049 | 25 | 265,918 | 8 | 91,126 | 25 | 94,192 | 26 |
| ≥80 | 71,449 | 18 | 138,195 | 4 | 65,065 | 18 | 67,911 | 19 |
| Gender | ||||||||
| Female | 191,444 | 47 | 1,646,653 | 52 | 177,264 | 48 | 178,754 | 49 |
| Male | 212,249 | 53 | 1,548,438 | 49 | 190,062 | 52 | 188,572 | 51 |
| Comorbid conditions | ||||||||
| Alcoholism | 7,611 | 2 | 31,268 | 1 | 6,530 | 2 | 7,015 | 2 |
| Non-bleeding ulcer diagnosis | 3,573 | 1 | 11,828 | 0 | 3,090 | 1 | 3,219 | 1 |
| Non-bleeding conditions from esophagus | 11,553 | 3 | 46,505 | 2 | 10,067 | 3 | 10,600 | 3 |
| Diabetes | 57,814 | 14 | 113,453 | 4 | 49,798 | 14 | 56,664 | 15 |
| Myocardial infarction | 34,253 | 9 | 9,105 | 0 | 16,776 | 5 | 9,104 | 3 |
| Congestive heart failure | 18,872 | 5 | 18,054 | 1 | 14,094 | 4 | 13,448 | 4 |
| Peripheral vascular disease | 20,825 | 5 | 19,997 | 1 | 15,936 | 4 | 15,129 | 4 |
| Cerebrovascular disease | 48,002 | 12 | 38,802 | 1 | 37,329 | 10 | 35,886 | 10 |
| Dementia | 6,184 | 2 | 9,815 | 0 | 5,323 | 1 | 5,544 | 2 |
| Chronic pulmonary disease | 25,434 | 6 | 71,478 | 2 | 21,475 | 6 | 22,673 | 6 |
| Connective tissue disease | 9,048 | 2 | 31,832 | 1 | 7,842 | 2 | 8,161 | 2 |
| Ulcer disease | 111 | 0 | 392 | 0 | 91 | 0 | 111 | 0 |
| Mild liver disease | 2,266 | 1 | 12,871 | 0 | 2,036 | 1 | 2,169 | 1 |
| Hemiplegia | 645 | 0 | 2,612 | 0 | 545 | 0 | 584 | 0 |
| Moderate to severe renal disease | 6,192 | 2 | 12,327 | 0 | 4,998 | 1 | 4,994 | 1 |
| Any tumor | 23,555 | 6 | 86,392 | 3 | 21,200 | 6 | 22,482 | 6 |
| Leukemia | 865 | 0 | 2,893 | 0 | 769 | 0 | 797 | 0 |
| Lymphoma | 1,933 | 1 | 6,137 | 0 | 1,731 | 1 | 1,836 | 1 |
| Moderate to severe liver disease | 457 | 0 | 2,368 | 0 | 419 | 0 | 450 | 0 |
| Metastatic solid tumor | 2,499 | 1 | 8,741 | 0 | 2,233 | 1 | 2,341 | 1 |
| AIDS | 233 | 0 | 2,105 | 0 | 188 | 0 | 201 | 0 |
| Concomitant medication use | ||||||||
| Oral anticoagulants | 21,500 | 5 | 50,212 | 2 | 19,213 | 5 | 21,989 | 6 |
| High-dose ASA | 61,067 | 15 | 47,223 | 2 | 46,312 | 13 | 43,752 | 12 |
| NSAIDs | 1,273 | 0 | 4,417 | 0 | 1,127 | 0 | 1,137 | 0 |
| Glucocorticoids | 31,071 | 8 | 126,701 | 4 | 27,351 | 7 | 29,017 | 8 |
| SSRIs | 39,845 | 10 | 191,574 | 6 | 34,934 | 10 | 37,814 | 10 |
| PPIs | 66,641 | 17 | 253,070 | 8 | 58,304 | 16 | 63,874 | 17 |
| Nitrates | 27,905 | 7 | 22,767 | 1 | 20,979 | 6 | 18,934 | 5 |
| Calcium antagonists | 82,788 | 21 | 185,278 | 6 | 72,051 | 20 | 79,474 | 22 |
| Statins | 115,557 | 29 | 226,428 | 7 | 99,031 | 27 | 109,607 | 30 |
| H2 antagonists | 7,090 | 2 | 26,467 | 1 | 6,215 | 2 | 6,413 | 2 |
Abbreviations: ASA, acetylsalicylic acid; SSRIs, selective serotonin reuptake inhibitors; PPIs, proton-pump inhibitors; NSAIDs, nonsteroidal anti-inflammatory drugs.