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(A) Histology of a primordial follicle with an oocyte surrounded partially or completely by flattened (squamous) pre-granulosa cells (arrow). (B) Histology of primary and pre-antral secondary follicles (both classified as developing) with an oocyte surrounded by one or more cuboidal granulosa cell layers (arrowhead). (C) Postnatal day 4 rat ovary cultured for 10 days with no treatment. (D) Postnatal day 4 rat ovary cultured for 10 days with GDNF treatment.
