Table 2.
GDNF-regulated gene expression in primordial follicles.
| Gene symbol and category | Control raw | GDNF raw | GDNF/Cont ratio | GenBank | Gene title |
|---|---|---|---|---|---|
| Cell cycle | |||||
| Cdc14a_predicted | 165 | 104 | 0.63 | AW915083 | CDC14 cell division cycle 14 homolog A |
| Cytoskeleton | |||||
| Jam2 | 126 | 204 | 1.62 | AA849471 | Junction adhesion molecule 2 |
| Spire1_predicted | 80 | 125 | 1.58 | H31747 | Spire homolog 1 (Drosophila) (predicted) |
| Growth factors | |||||
| Amh | 146 | 219 | 1.50 | AI059285 | Anti-Müllerian hormone |
| Ctgf | 505 | 716 | 1.42 | NM_022266 | Connective tissue growth factor |
| Fgf8 | 22 | 40 | 1.80 | NM_133286 | Fibroblast growth factor-8 |
| Gdf9 | 626 | 951 | 1.52 | NM_021672 | Growth differentiation factor-9 |
| Stc1 | 644 | 392 | 0.61 | BF552244 | Stanniocalcin-1 |
| Development | |||||
| Lrrn3 | 66 | 107 | 1.62 | NM_030856 | Leucine-rich repeat protein-3, neuronal |
| Metabolism and transport | |||||
| Arg2 | 239 | 396 | 1.66 | NM_019168 | Arginase-2 |
| Aqp9 | 185 | 115 | 0.62 | NM_022960 | Aquaporin-9 |
| Ldhc | 62 | 99 | 1.61 | NM_017266 | Lactate dehydrogenase C |
| Sardh | 92 | 57 | 0.63 | AI103641 | Sarcosine dehydrogenase |
| LOC684802///LOC685152 | 76 | 49 | 0.65 | BI273855 | Similar to probable phospholipid transporting |
| RGD1565367_predicted | 124 | 66 | 0.53 | C07059 | Similar to solute carrier family 23, member 2 |
| Receptor and binding Pr | |||||
| Il17re | 127 | 83 | 0.65 | BM383766 | Interleukin 17 receptor E |
| Trpc3 | 248 | 153 | 0.62 | NM_021771 | Transient receptor potential cation channel |
| Transcription/epigenetic | |||||
| Arid1b | 136 | 86 | 0.63 | AI556402 | AT-rich interactive domain 1B (Swi1 like) |
| Irx3_predicted | 333 | 213 | 0.64 | AI713965 | Iroquois-related homeobox 3 (Drosophila) |
| ESTs | |||||
| RGD1308734 | 84 | 140 | 1.66 | BI285951 | Similar to RIKEN cDNA 1100001H23 |
| – | 103 | 61 | 0.59 | BM391972 | CDNA clone IMAGE:7366335 |
| RGD1310110_predicted | 116 | 176 | 1.52 | AI501165 | Similar to 3632451O06Rik protein (predicted) |
| RGD1307390_predicted | 80 | 123 | 1.54 | BI295093 | Similar to BC282485_1 (predicted) |
| RGD1309888 | 164 | 107 | 0.65 | BG371863 | Similar to RIKEN cDNA 1500002O20 |
| – | 159 | 101 | 0.64 | BF396928 | Transcribed locus |
| – | 122 | 79 | 0.65 | BE109251 | Transcribed locus |
| – | 104 | 61 | 0.59 | BF283840 | Transcribed locus |
| – | 123 | 201 | 1.64 | BM386842 | Transcribed locus, strongly similar to XP_001086149 |
| – | 165 | 96 | 0.58 | BE117343 | – |
| – | 457 | 257 | 0.56 | AI058976 | – |
Microarray of control and GDNF-treated postnatal day 4 rat ovaries after 2 days of culture.