Figure 1.

Depiction of androgen receptor isoforms. Panel (A) depicts protein isoforms and highlights the three crucial domains of hAR for proper protein function. The shorter isoform lacks a portion of the N-terminal domain (NTD) and could play an important role in androgen-resistance.⁹⁶ The other domains DBD and LBD are depicted in both isoforms. The nuclear localization signal (NLS) is contained within the DBD and denoted as a blue square. The NLS is also located in the hinge portion of the DBD and is denoted with a letter H. (B) Depiction of the 3′-UTRs of the three hAR RNA isoforms, as well as the most well conserved miRNA binding sites. These sites are considered putative sites via TargetScan.