Table 1.
Associations with lnFXI in the discovery and replication studies, fixed-effect meta-analysis
| rs | Chr:pos | A1/A2 | FreqA1 | Betadisc (SE) | Pdisc (Phet) | Betarepl (SE) | Prepl (Phet) |
|---|---|---|---|---|---|---|---|
| Discovery | |||||||
| rs710446 | 3:186459927 | T/C | 0.590 | −0.0888 (0.00239) | 2.07 × 10−302 (1.76 × 10−05) | −0.125 (0.00944) | 9.74 × 10−40 (5.55 × 10−16) |
| rs4253417 | 4:187199005 | T/C | 0.592 | −0.0735 (0.00248) | 2.86 × 10−193 (2.23 × 10−07) | −0.0898 (0.00983) | 6.9 × 10−20 (1.11 × 10−15) |
| rs780094 | 2:27741237 | T/C | 0.407 | 0.0147 (0.00249) | 3.56 × 10−09 (0.0562) | 0.0238 (0.00965) | 0.0137 (0.262) |
| Conditional | |||||||
| rs4253421 | 4:187204937 | A/G | 0.118 | −0.0498 (0.00373) | 1.25 × 10−40 (5.45 × 10−4) | – | – |
| rs76438938 | 3:186461524 | C/T | 0.971 | −0.0765 (0.00711) | 6.07 × 10−27 (0.00211) | – | – |
Results from the GWAMA analysis, number of tested SNPs in the discovery analysis are 7,353,638 and for the conditional analyses 7,353,629. A1 = allele 1 A2 = allele 2. For SNPs displaying inflated heterogeneity (rs710446, rs4253417 andrs4253421) in an analysis, a random-effect version of the analysis was performed; in all cases, these analyses confirmed the discovered associations for the investigated SNPs (Supplementary Material, Table S2, S3, and S5).