Table 6.
rs_locus | A1 | A2 | Freq1 | Beta | SE | P-value | Direction | P_het |
---|---|---|---|---|---|---|---|---|
Model 1 | ||||||||
rs710446 | C | T | 0.412164 | −0.296423 | 0.009575 | 2.29 × 10−210 | — | 6.10 × 10−04 |
rs4253417 | C | T | 0.419123 | −0.118784 | 0.009575 | 2.65 × 10−35 | — | 0.194202 |
rs4253421 | G | A | 0.885623 | −0.083696 | 0.009575 | 2.44 × 10−18 | −+– | 0.130280 |
rs76438938 | T | C | 0.028115 | −0.056257 | 0.009575 | 4.33 × 10−09 | — | 0.877173 |
rs780094 | C | T | 0.592274 | 0.014700 | 0.009575 | 0.124693 | +++ | 0.770329 |
Model 2 | ||||||||
rs710446 | C | T | 0.411999 | −0.204035 | 0.009579 | 1.28 × 10−100 | — | 4.54 × 10−05 |
rs4253417 | C | T | 0.418964 | −0.042991 | 0.009579 | 7.28 × 10−06 | −+– | 0.614175 |
rs4253421 | G | A | 0.885574 | −0.031183 | 0.009579 | 0.001138 | − ++ | 0.255919 |
rs76438938 | T | C | 0.028138 | −0.007322 | 0.009579 | 0.444662 | − +++ | 0.280294 |
rs780094 | C | T | 0.592396 | −0.004186 | 0.009579 | 0.662094 | −+– | 0.700256 |
Results from the GWAMA fixed-effect meta-analysis based on normalized beta and standard errors. Because of the inflated heterogeneity for rs710446 in both model 1 and model 2 analyses, we performed a random-effect version of these analyses that confirmed the discovered association for this SNP (Supplementary Material, Table S9).