Table 3.

Data on immunotherapy as single agent for the first-line treatment of NSCLC

	CheckMate-02642	KeyNote-02443
Immunotherapy vs ICPD	Nivolumab	Pembrolizumab
ORR vs ICPD	26% vs 34%	45% vs 28%
Median PFS vs ICPD	4.2 m vs 5.9 m	10.3 m vs 6.0 m
Median OS vs ICPD	14.4 m vs 13.2 m	NR both arms
HR for OS (95% CI) PD-L1≥5%	1.02 (0.80 to 1.30)	NA
HR for OS (95% CI) PD-L1≥50%	0.90 (0.67 to 1.32)	0.60 (0.41 to 0.89)

ICPD, immune-check points drug; NA, not applicable; NSCLC, non-small cell lung cancer; ORR, objective response rate; OS, overall survival; PFS, progression-free survival.