Table 1.

Major differences between right colon cancer (RCC) and left colorectal cancer (LCRC)

	RCC	LCRC
Incidence	Lower than LCRC	Higher than RCC
	Increasing	Decreasing
	Higher in female	Higher in male
Presentation	Higher TNM stage	Lower TNM stage
	Larger tumours	Smaller tumour
	More mucinous type	Less mucinous type
Genetics	Common site for CRC in MUTYH-associated polyposis	Common site for CRC in familial adenomatous polyposis
Immunology	More active immune cells promoting immunogenicity	Immunosuppressive cells highly represented, promoting tolerogenesis
Molecular pathway	CIMP/MSI/BRAF positive tumours	Chromosomal instability
Outcomes	Worse overall survival	Better overall survival

Adapted from Lee et al 11.

CIMP, CPG island methylation phenotype; MSI, microsatellite instability.