Fig. 4.

Evaluation of equivalent diffusion coefficient for tissue by numerical homogenization. (a) Extracellular fibrous space of skin [39] and simplified model of reference volume (RV) used for computational model; (b) Scaling function for doxorubicin molecule interacting with tissue; (c) Mass release curve used as the constitutive curve for diffusive transport; (d) Concentration distribution along a line (aligned with the flux direction) of the RV at a time t=0.1s, for the detailed (true) and equivalent model; (e) Diffusion coefficient for free diffusion in the liquid (D_bulk) and equivalent diffusion coefficient in terms of concentration.