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. 2017 Nov 27;12(11):e0188071. doi: 10.1371/journal.pone.0188071

Fig 2. Coxiella interactions in the endoplasmic reticulum protein-processing pathway.

Fig 2

The interacting host proteins are highlighted in red text and the pathogen proteins are superimposed as named yellow circles and located close to their interacting host partners. Overlaying the interacting C. burnetii proteins onto their human partners in Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways illustrates intervention points of nine screened Coxiella effectors that could affect human-host protein processing in the endoplasmic reticulum (ER). Pathogen proteins can multiply their effect by interacting with multiple host proteins or focus their effect by using different pathogen proteins to target the same host protein. The potential effect of these interactions could influence multiple processes, such as protein export, COPII-mediated vesicle formation, initiation of apoptosis, and ER-assisted protein degradation. In this pathway representation, CBUA0014 interacts with Hsp40 and Skp1; CBU1379a with BiP; CirA with PERK; CirC with ERManI; CBU0794 with Calpain and Sec23/24; CBU1724 with Cul1; and CBU1457 with Cul1. The underlying network graph is reprinted from KEGG [40] under a CC BY license, with permission from the Kanehisa Laboratories, original copyright 2016.