Table 3. Responses from 250,000 CD8+ T cells ex vivo to peptide-pulsed autologous DC.
| Peptide ID | Peptide Source Protein | Peptide Sequence | Responding Donors | IFNγ-SFU |
|---|---|---|---|---|
| 5 | EsxG67-84 | TLLDVAQANLGEAAGTYV | D481 (TB) | 5.5 |
| 9 | LpqI88-100 | VGGILIGSDTDLT | D519 (H) | 16 |
| 10 | EsxG2-11 | SLLDAHIPQL | D454a (LTBI) | 48.5 |
| 12 | EsxG3-11 | LLDAHIPQL | D454a (LTBI) | 24.5 |
| 15 | EsxA85-95 | STEGNVTGMFA | D519 (H) | 13 |
| 16 | LpqI89-100 | GGILIGSDTDLT | D698 (TB) | 52.5 |
| D454a (LTBI) | 31.5 | |||
| D584 (LTBI) | 66.5 | |||
| D603a (LTBI) | 70 | |||
| 23 | Rv0634A19-29 | EIEVDDDLIQK | D480 (TB) | 14.5 |
| D481 (TB) | 38 | |||
| D698 (TB) | 44.5 | |||
| D454a (LTBI) | 102.5 | |||
| D557 (LTBI) | 14.5 | |||
| D584 (LTBI) | 70.5 | |||
| D603a (LTBI) | 114 | |||
| D673 (LTBI) | 21 | |||
| D732 (LTBI) | 10.5 | |||
| D444 (H) | 27 | |||
| D497 (H) | 37 | |||
| D519 (H) | 111 | |||
| D520 (H) | 9.5 | |||
| 26 | Rv3479900-911 | S(+42.01)TIIAGALLLVLb | D480 (TB) | 9.5 |
| 27 | Rv3479900-911 | STIIAGALLLVL | D480 (TB) | 25.5 |
| D732 (LTBI) | 22.5 | |||
| 28 | EsxG3-10 | LLDAHIPQ | D519 (H) | 10 |
| 32 | EsxH4-12 | IMYNYPAML | D584 (LTBI) | 22.5 |
| D603a (LTBI) | 47 | |||
| D519 (H) | 47 | |||
| 34 | PE54-13 | RVVPEGLAAA | D564 (LTBI) | 15.5 |
aIndicates donor is HLA-A2
bPeptide is acetylated at amino acid 900
TB: Active TB donor
LTBI: Latent TB donor
H: Healthy donor