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. 2017 Nov 27;12(11):e0188097. doi: 10.1371/journal.pone.0188097

Table 4. Unadjusted and adjusted* Cox proportional hazards regression for all-cause mortality for diabetic foot non-diabetic foot in the registered diabetic patients.

Variables Diabetic foot Diabetic patients without foot complications
Unadjusted HR (95% CI) P value Adjusted HR (95% CI)* P value Unadjusted HR (95% CI) P value Adjusted HR (95% CI)* P value
Macrovascular complications 2.07(1.56–2.75) <0.001 1.60(0.99–2.59) 0.056 2.90(1.91–4.42) <0.001 1.42(0.80–2.52) 0.237
Nephropathy 1.92(1.44–2.54) <0.001 1.82(1.13–2.95) 0.014 2.12(1.33–3.38) 0.002 1.79(0.97–3.29) 0.061
Diabetes duration ≥ 10 years 1.89(0.84–4.27) 0.124 1.15(0.35–3.80) 0.816 2.06(0.65–6.50) 0.220 2.57(0.35–19.04) 0.356
Male gender 1.80(2.29–2.51) 0.001 1.58(0.93–2.71) 0.092 1.42(0.89–2.27) 0.142 0.86(0.47–1.59) 0.626
Hypertension 1.55(1.16–2.09) 0.004 1.55(0.96–2.50) 0.075 2.24(1.41–3.55) 0.001 1.56(0.82–2.97) 0.172
Age 1.03(1.02–1.05) <0.001 1.02(0.99–1.04) 0.109 1.07(1.05–1.09) <0.001 1.07(1.04–1.09) <0.001
Smoking 1.56(0.95–2.56) 0.078 1.77(0.92–3.41) 0.085 1.66(0.72–3.86) 0.238 2.12(0.80–5.63) 0.133
Retinopathy 1.26(0.94–1.69) 0.121 0.75(0.46–1.22) 0.248 1.63(1.06–2.52) 0.027 1.37(0.78–2.40) 0.278
BMI <25 kg/m2 1.13(0.73–1.75) 0.58 0.84(0.49–1.45) 0.527 1.25(0.65–2.39) 0.503 1.58(0.47–5.38) 0.461
BMI >35 kg/m2 0.54(0.29–0.99) 0.046 0.53(0.25–1.14) 0.104 0.76(0.34–1.71) 0.506 0.78(0.29–2.05) 0.609
Hyperlipidemia 0.67(0.49–0.92) 0.013 0.42(0.24–0.73) 0.002 0.90(0.58–1.38) 0.627 1.07(0.60–1.90) 0.816
Neuropathy 0.61(0.09–4.35) 0.622 0.42(0.05–3.44) 0.421 1.17(0.72–1.91) 0.526 0.94(0.50–1.75) 0.835
Insulin use 0.97(0.74–1.34) 0.98 1.05(0.66–1.67) 0.845 1.15(0.76–1.74) 0.511 0.98(0.56–1.72) 0.979

* Adjusted for all characteristics listed in the table

BMI 25–29.9 kg/m2 as a reference group