Table 4. Unadjusted and adjusted* Cox proportional hazards regression for all-cause mortality for diabetic foot non-diabetic foot in the registered diabetic patients.
Variables | Diabetic foot | Diabetic patients without foot complications | ||||||
---|---|---|---|---|---|---|---|---|
Unadjusted HR (95% CI) | P value | Adjusted HR (95% CI)* | P value | Unadjusted HR (95% CI) | P value | Adjusted HR (95% CI)* | P value | |
Macrovascular complications | 2.07(1.56–2.75) | <0.001 | 1.60(0.99–2.59) | 0.056 | 2.90(1.91–4.42) | <0.001 | 1.42(0.80–2.52) | 0.237 |
Nephropathy | 1.92(1.44–2.54) | <0.001 | 1.82(1.13–2.95) | 0.014 | 2.12(1.33–3.38) | 0.002 | 1.79(0.97–3.29) | 0.061 |
Diabetes duration ≥ 10 years | 1.89(0.84–4.27) | 0.124 | 1.15(0.35–3.80) | 0.816 | 2.06(0.65–6.50) | 0.220 | 2.57(0.35–19.04) | 0.356 |
Male gender | 1.80(2.29–2.51) | 0.001 | 1.58(0.93–2.71) | 0.092 | 1.42(0.89–2.27) | 0.142 | 0.86(0.47–1.59) | 0.626 |
Hypertension | 1.55(1.16–2.09) | 0.004 | 1.55(0.96–2.50) | 0.075 | 2.24(1.41–3.55) | 0.001 | 1.56(0.82–2.97) | 0.172 |
Age | 1.03(1.02–1.05) | <0.001 | 1.02(0.99–1.04) | 0.109 | 1.07(1.05–1.09) | <0.001 | 1.07(1.04–1.09) | <0.001 |
Smoking | 1.56(0.95–2.56) | 0.078 | 1.77(0.92–3.41) | 0.085 | 1.66(0.72–3.86) | 0.238 | 2.12(0.80–5.63) | 0.133 |
Retinopathy | 1.26(0.94–1.69) | 0.121 | 0.75(0.46–1.22) | 0.248 | 1.63(1.06–2.52) | 0.027 | 1.37(0.78–2.40) | 0.278 |
BMI <25 kg/m2† | 1.13(0.73–1.75) | 0.58 | 0.84(0.49–1.45) | 0.527 | 1.25(0.65–2.39) | 0.503 | 1.58(0.47–5.38) | 0.461 |
BMI >35 kg/m2† | 0.54(0.29–0.99) | 0.046 | 0.53(0.25–1.14) | 0.104 | 0.76(0.34–1.71) | 0.506 | 0.78(0.29–2.05) | 0.609 |
Hyperlipidemia | 0.67(0.49–0.92) | 0.013 | 0.42(0.24–0.73) | 0.002 | 0.90(0.58–1.38) | 0.627 | 1.07(0.60–1.90) | 0.816 |
Neuropathy | 0.61(0.09–4.35) | 0.622 | 0.42(0.05–3.44) | 0.421 | 1.17(0.72–1.91) | 0.526 | 0.94(0.50–1.75) | 0.835 |
Insulin use | 0.97(0.74–1.34) | 0.98 | 1.05(0.66–1.67) | 0.845 | 1.15(0.76–1.74) | 0.511 | 0.98(0.56–1.72) | 0.979 |
* Adjusted for all characteristics listed in the table
† BMI 25–29.9 kg/m2 as a reference group