Table 2. Hemodynamic parameters at baseline and at 1 year in different hemodynamic subgroups.
| Baseline | 1 year | Time effect | Group effect | |||||||
|---|---|---|---|---|---|---|---|---|---|---|
| No-PH | CpC-PH | Ipc-PH | PreC-PH | No-PH | CpC-PH | Ipc-PH | PreC-PH | P value | P value | |
| n = 98 | N = 75 | N = 111 | N = 11 | n = 98 | N = 75 | N = 111 | N = 11 | |||
| Systolic BP, mmHg | 106.8 (17.3) | 103.7 (14.4) | 100.9 (15.3) | 109.3 (16) | 137.3 (15.7) | 138.5 (17.1) | 136.5 (14.7) | 135 (14.5) | 0.18 | <0.001 |
| Diastolic BP, mmHg | 68.8 (11.8) | 67.5 (11.5) | 66.5 (11.6) | 69.5 (11.7) | 88.5 (12.8) | 89.9 (12.2) | 87.3 (11.2) | 93 (11.8) | 0.24 | <0.001 |
| Heart Rate, bpm | 71.4 (13.4) | 79.6 (15.3) | 77.7 (14.5) | 81.7 (14) | 82.4 (11.3) | 85.2 (11.9) | 84.4 (11.4) | 85.2 (10.2) | <0.001 | <0.001 |
| Mean BP, mmHg | 81.5 (12.7) | 79.5 (11.4) | 78 (11.1) | 82.8 (12.4) | 104.7 (12.9) | 106.1 (12.6) | 103.7 (11.1) | 97.3 (34.1) | 0.23 | <0.001 |
| Systolic PAP, mmHg | 28 (7.9) | 56.2 (10.9) | 47.4 (8.1) | 49.7 (16.2) | 23.7 (5.4) | 26.3 (7.1) | 24 (6.6) | 24.8 (6.1) | <0.001 | <0.001 |
| Mean PAP, mmHg | 18 (5) | 39.1 (6.3) | 33.4 (4.8) | 32.7 (8.8) | 14.7 (4.4) | 16.4 (5.2) | 14.6 (4.9) | 14 (3) | <0.001 | <0.001 |
| Diastolic PAP, mmHg | 11.7 (4.7) | 27.4 (6.5) | 23.6 (5.3) | 19.4 (7.6) | 7.8 (4.6) | 8.4 (4.3) | 7.6 (4.6) | 7.1 (3.4) | <0.001 | <0.001 |
| TPG, mmHg | 6.3 (2.9) | 12.2 (3.8) | 6.3 (2.5) | 20.6 (11.6) | 7.2 (3.3) | 8.7 (3.9) | 7.3 (3.5) | 7.2 (3.9) | <0.001 | <0.01 |
| DPG, mmHg | 0 (3.2) | 0.5 (5.3) | -3.5 (3.8) | 7.3 (10.5) | 0.3 (3.7) | 0.8 (3.4) | 0.4 (3.2) | 0.3 (4.2) | <0.001 | <0.001 |
| Cardiac Index, L/min/m2 | 2.1 (0.5) | 1.6 (0.4) | 1.9 (0.4) | 1.6 (0.3) | 2.9 (0.6) | 2.8 (0.6) | 3 (0.6) | 2.5 (0.7) | <0.001 | <0.001 |
| Cardiac Output, L/min | 3.7 (1) | 2.9 (0.8) | 3.4 (0.9) | 2.7 (0.7) | 5.4 (1.2) | 5.1 (1.1) | 5.4 (1.3) | 4.7 (1.4) | <0.001 | <0.001 |
| RAP, mmHg | 4.7 (4.6) | 9.3 (5.5) | 9.4 (6.3) | 10.3 (10.5) | 3.9 (3.4) | 3.6 (3.3) | 3.8 (3.7) | 2.3 (0.9) | <0.001 | <0.001 |
| PAWP, mmHg | 11.7 (5.2) | 26.8 (5.5) | 27.1 (5.2) | 12.1 (3.8) | 7.5 (3.7) | 7.6 (4.1) | 7.3 (4.4) | 6.8 (3.1) | <0.001 | <0.001 |
| PVR, mmHg/(L/min) | 1.8 (1) | 4.3 (1.4) | 1.9 (0.7) | 8.5 (6.6) | 1.4 (0.7) | 1.8 (0.9) | 1.4 (0.8) | 1.7 (0.9) | <0.001 | <0.001 |
| Pulmonary Ca, ml/mmHg | 3.7 (2) | 1.6 (1.2) | 2.1 (1.1) | 1.3 (0.6) | 4.5 (1.8) | 3.7 (1.4) | 4.5 (2.6) | 3.5 (1.5) | <0.001 | <0.001 |
| Systemic Ca, ml/mmHg | 1.5 (0.5) | 1.1 (0.5) | 1.5 (0.7) | 1 (0.5) | 1.4 (0.5) | 1.3 (0.5) | 1.4 (0.4) | 1.4 (0.5) | <0.001 | 0.98 |
| Stroke Volume, ml | 52.6 (15.9) | 38.2 (12.6) | 45 (14.4) | 34.7 (12.9) | 65.4 (14.5) | 60.5 (15.5) | 63.9 (14.2) | 55 (16.9) | <0.01 | <0.001 |
BP = blood pressure; PAP = pulmonary artery pressure; TPG = transpulmonary gradient: DPG = diastolic pulmonary gradient; RAP = right atrial pressure; PAWP = pulmonary artery wedge pressure; PVR = pulmonary vascular resistance; Ca = compliance.