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. 2017 Nov 27;12(11):e0188333. doi: 10.1371/journal.pone.0188333

Fig 1. Genome-wide siRNA screening identifies 18 genes that modulate replication of poliovirus (PV), rotavirus (RV) or influenza A virus (IAV).

Fig 1

Vero cells were reverse transfected with non-targeting control (NTC) / gene specific on-target plus (OTP) siRNAs (50nM) for 48h followed by infection with PV (A), RV (B) or IAV (C). Effect of gene knockdown on viral replication is shown as fold-change relative to NTC from pooled samples. Data represent plaque numbers (A and C) and absorbance (λ = 450nm) for (B). Error bars represent ±SEM from three independent experiments. * p<0.05 **p<0.01 ***p<0.001 ****p<0.0001.