Fig. 6.

Proposed alternation of B[a]P metabolism pathway after initial LPS-induced inflammation. This pathway is based on our transcriptome analysis together with previous phenotypic analyses, suggesting that LPS inhibits Cyp1a1, epoxide hydrolase, GSTs, SULTs. Although UGTs are up-regulated by LPS, β-glucuronidase, which could convert UGTs conjugated Ba]P metabolites into their free form, is also up-regulated. Finally, LPS enhanced the B[a]P-induced DNA damage by forming BPDE-DNA adducts.