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. 2017 Nov 23;8:1586. doi: 10.3389/fimmu.2017.01586

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Copyright © 2017 Blatt, Saggu, Cortes, Herbert, Kavanagh, Ricklin, Lambris and Ferreira.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effects of rH19–20 mutants on platelet/granulocyte aggregate (PGA) formation correlate with effects on C3 fragment deposition, C5a generation, and CD11b expression. The mean effect of each mutant on PGA formation relative to wild-type (WT) (red; assigned a value of 1) is graphed on the X-axis, and the mean effect of each mutant on (A) C3 fragment deposition, (B) C5a generation, and (C) CD11b expression relative to WT is graphed on the Y-axis. Data were analyzed by Pearson’s correlation test. The r value is displayed on each panel. p < 0.001 for all panels.