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. 2017 Nov 27;7:16406. doi: 10.1038/s41598-017-16618-5

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Liver histology and glucose tolerance test (GTT). When compared to the WT (A and B), the histology showed that both the Hsd17b1-LacZ/Neo and Naglu-Neo mice had lipid accumulation in the liver, as indicated by HE staining (C and E) and by Oil Red O staining (D and F). Glucose tolerance was improved in the Naglu-Neo mice (n = 9–10) despite the hepatic lipid accumulation (G). The P value is 0.0293. Error bars show SD.