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. 2017 Nov 23;8:946. doi: 10.3389/fphys.2017.00946

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Copyright © 2017 Ni, Whittaker, Wang, Giles, Narayan and Zhang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Frequency-dependent inhibition of I_Kur by acacetin. (A) Experimental and (B) simulated traces of K_V1.5 channel current elicited from the 20th voltage step repeating at 0.5 and 4 Hz in control (left) and after exposure to 3 μM of acacetin (right). (C) Relative remaining I_Kur following application of acacetin at various frequencies plotted against the pulse number of the voltage step. The simulated data (lines) were compared with experimental values (squares). The relative fraction was obtained by normalizing the end-step current measured from each pulse following application of acacetin to that of control. Experimental data were digitalized from Wu et al. (2011).