Figure 3.

Simulated AP and I_Na traces of cAF-remodeled atrial myocytes and ventricular cells in response to Na⁺- and K⁺- block regimens. (Ai) APs from cAF-remodeled atrial myocytes paced at 1 Hz; (Aii) Time courses of corresponding I_Na during the upstroke phase. (B) Simulated time courses of AP and I_Na of a ventricular cell paced at 1 Hz. (C) Illustration of (i) APs and (ii) the corresponding time courses of I_Na of a cAF-remodeled myocyte paced at 6 Hz. In these simulations, rate constants for I_Na blocker were: K_A = 100 ms⁻¹· M⁻¹, K_I = 100 ms⁻¹· M⁻¹, I_A = 1 ms⁻¹, I_I = 0.01 ms⁻¹.