Figure 6.

Block efficacy, and the rate-, atrial-, and AF-selectivity as a function of the open- and inactivated- state binding rates (K_A, K_I) for Na⁺-block or combined Na⁺- and K⁺-block computed from cAF-remodeled atrial myocytes or ventricular myocytes. (A) Block efficacy; (B) rate-selectivity; (C) atrial-selectivity, and (D) AF-selectivity. In each column shown are data from Bl·INa (i), combined Bl·INa and Bl·IKur (ii), and combined Bl·INa and Comb·Bl·IX (iii). $L_A=1\text{ m}{\text{s}}^{-1},L_I=0.01\text{ m}{\text{s}}^{-1}$. Unit of K_A, K_I: ms⁻¹·M⁻¹.