Figure 7.

Snapshots of simulated re-entrant excitation events, tip trajectories of re-entrant waves and the number of rotor in a 2D model of cAF-remodeled atrial tissue slab in drug-free condition or after applying the drugs. (A) Snapshots of simulated re-entrant excitation events; The time sequence (ms) is indicated at the top left corner of each screenshot. (B) Tip trajectories of re-entrant waves. (C) Temporal evolution of total number of rotors represented by the number of spiral wave tips in tissue. In both (A,B), (i) Drug-free (CTL) condition, (ii) Bl·I_Na alone, (iii) Bl·I_Kur alone, (iv) Combined Bl·I_Na and Bl·I_Kur, (v) Applying Comb·Bl·I_X alone, and (vi) Combined Bl·I_Na and Comb·Bl·I_X. Rate constants for I_Na block: $K_A=1\text{ m}{\text{s}}^{-1}·{\text{M}}^{-1},K_I=100\text{ m}{\text{s}}^{-1}·{\text{M}}^{-1},L_A=1\text{ m}{\text{s}}^{-1},L_I=0.01\text{ m}{\text{s}}^{-1}$.