TABLE 3.
Concordance, Se, Sp, PPV, NPV, Youden index, and Yule Q by testing 767 nonselected samples for anti-Toxoplasma IgG and/or IgMd
| Test | Concordance with ICT (%) | Sea (%) | NPV (%) | Spb (%) | PPV (%) | Youden index (Se + Sp − 1) | Yule Q (%) |
|---|---|---|---|---|---|---|---|
| ICT for IgG | NAc | 100 (98.5–100) | 100 (98.5–100) | 98.7 (97.8–99.6) | 95.8 (94.2–97.4) | 0.99 | 100 |
| Architect IgG (cutoff, 1.6 IU/ml) | 97.2 (96.0–98.4) | 92.1 (88.1–96.1) | 97.7 (95.5–99.8) | 99.8 (99.4–100) | 99.4 (98.8–100) | 0.92 | 100 |
| Architect IgG (cutoff, 3.0 IU/ml) | 94.5 (92.9–96.1) | 80.7 (74.9–86.5) | 94.6 (91.3–97.9) | 100 (99.6–100) | 100 (99.6–100) | 0.81 | 100 |
| ICT for IgM | NA | 100 (92.6–100) | NA | 100 (98.3–100) | NA | NA | NA |
| Architect IgM (cutoff, 0.5 AU/ml) | 99.6 (99.1–100) | 96.1 (88.7–100) | NA | 99.6 (98.3–100) | NA | NA | NA |
| Architect IgM (cutoff, 0.6 AU/ml) | 99.1 (98.4–99.8) | 80.8 (65.7–95.9) | NA | 99.7 (98.3–100) | NA | NA | NA |
a
Se, sensitivity defined as true positive/(true positive + false negative).
b
Sp, specificity defined as true negative/(true negative + false positive).
c
NA, not applicable.
d
Values in parentheses are 95% confidence intervals.