TABLE 2.

Comparative summary of TTD observations using microbiology laboratory detection instruments for BC bottles containing antimicrobial binding agents^a

Antibiotic	Concn category	Mean TTD (h) ± SD				P valueb
		Bactec Plus Aerobic Plus/F		BacT/Alert FA Plus Aerobic
		P. aeruginosa ATCC 27853	P. aeruginosa 147	P. aeruginosa ATCC 27853	P. aeruginosa 147
Meropenem	Peak	NG	17.8 ± 0.4	NG	18.8 ± 0.4	0.130
	Midpoint	NG	18 ± 0	NG	18.5 ± 0.7	0.419
	Trough	18.6 ± 0.5	18 ± 0	24 ± 1.4	18.5 ± 0.7	0.122
Ceftolozane-tazobactam	Peak	NG	NG	NG	NG	ND
	Midpoint	NG	NG	NG	NG	ND
	Trough	24.8 ± 0.4	18.6 ± 0.9	26c	21.5 ± 0.7	0.622
Ceftazidime-avibactam	Peak	NG	46.8 ± 1.8	NG	NG	ND
	Midpoint	20c	17.8 ± 0.4	NG	21.8 ± 0.4	0.061
	Trough	18.3 ± 1.1	17.5 ± 0	21 ± 2.8	19.3 ± 0.4	0.077

^aData are presented as mean TTDs (hours) ± standard deviations for duplicates. NG, no growth detected; ND, not done.

^bP values represent comparisons between Bactec and BacT/Alert bottles at specific antibiotic concentrations for all P. aeruginosa cultures that grew.

^cOnly a single TTD was reported due to a lack of growth in a duplicate experiment.