TABLE 3.
Percent reduction in meropenem, ceftolozane, and ceftazidime concentrations over 12 h in Bactec Plus Aerobic/F and BacT/Alert FA Plus Aerobic blood culture bottles inoculated with peak antibiotic concentrations
| Antimicrobial agent (target concn at 0 h in bottle [μg/ml]) | Mean % reduction of observed concn ± SDa |
|||||
|---|---|---|---|---|---|---|
| 0–10 min |
4 h |
12 h |
||||
| Bactec | BacT/Alert | Bactec | BacT/Alert | Bactec | BacT/Alert | |
| Meropenem (10) | 61.7 ± 26.2 | 68.6 ± 3.0 | 76.5 ± 16.9 | 83.3 ± 1.2 | 86.4 ± 9.6 | 90.6 ± 1.4 |
| Ceftolozane (37.5) | 15.5 ± 1.3 | 40.8 ± 13.4 | 28.5 ± 4.0 | 49.5 ± 4.2 | 39.4 ± 1.5 | 62.3 ± 10 |
| Ceftazidime (22.5) | 41.6 ± 1.6 | 44.3 ± 7.9 | 53.6 ± 2.7 | 57.0 ± 7.5 | 68.3 ± 1.2 | 69.9 ± 6.3 |
a
Data are presented as mean percent reductions ± standard deviations of observed concentrations in samples obtained at the specified time points relative to the target concentration in peak-concentration bottles at 0 h. The target peak concentration in the BC bottles is the plasma concentration diluted 4-fold by the volume in each bottle.