Figure 2.

Representative light microscopy sections of lung tissues of control mice and those treated with adenine mixed in the feed (0.2% w/w, for 4 weeks), stained with H&E or Masson's trichrome or Sirius red. All magnifications: 400X. The control group shows normal lung architecture and histology. Adenine-treated group shows polymorphonuclear leukocyte infiltration in alveolar and bronchial walls, injury, and fibrosis. See this figure for statistical analysis of scores of lung injury and fibrosis.