Table 1.

Some physiological and biochemical parameters in and urine of control mice and those which received adenine administration in the feed (0.2% w/w, for 4 weeks).

Parameters/Group	Control	Adenine
Urine output (ml/24 h)	3.0 ± 0.4	10.3 ± 1.2**
Change in body weight (%)	3.2 ± 2.2	−12.3 ± 1.2**
Urea (μmol/l)	6.1 ± 0.5	18.2 ± 1.3**
Creatinine (μmol/l)	14.5 ± 0.7	22.0 ± 1.3**
Creatinine clearance (ml/min)	0.2 ± 0.04	0.09 ± 0.008*

Values in the table are mean ± SEM (n = 6). Adenine was added to the feed at a concentration of 0.2% w/w, for 4 weeks.

^*P < 0.05 and

^**P < 0.001 (control vs. adenine group).