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Schematic description of pharmacological and non-pharmacological strategies for PD management and its relation with adenosinergic signaling. Block of A2AAR by antagonist induces reduction of positive effects over Adenylyl cyclase and negative effects over D2R signaling. Block of mGlu5R reduces its positive effects over Adenilyl cyclase through release of Ca2+. Recent studies with non-phamacological strategies for PD have been related it with adenosine receptors expression.
