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Scheme representing eCB-induced synaptic regulation at different levels of observation. eCBs released by ND induces synapse-specific modulation (green) through direct activation of cannabinoid receptors type 1 (CB1Rs) at presynaptic terminals (left) or through indirect activation of astrocytes (right). These synapse-specific phenomena observed at single synapses are concealed when monitoring synapse ensemble or synapse population.
